Clinical Oncology Letters
Clinical Oncology Letters
Artigo Original

Paullinia cupana (Guarana) for Chemotherapy-Induced Fatigue in Patients with Solid Tumors: A Meta-Analysis

Paullinia cupana (Guaraná) para fadiga induzida por quimioterapia em pacientes com tumores sólidos: uma meta-análise

Cicilia Marques Rodrigues, Auro del Giglio

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Objective: To review the literature systematically to summarize all retrievable existent data on the anti-fatigue effects of Paullinia cupana in chemotherapy-treated patients. Methods: Between September 2017 and December 2017 in the PUBMED, MEDLINE and Cochrane Library databases for publications in English of adult human studies (19 years or older) of patients with solid tumors undergoing chemotherapy who received Paullinia cupana versus placebo for fatigue. We employed the following MeSH (Medical Subject Headings) descriptors: fatigue, guarana (Paullinia) and chemotherapy. We also searched the bibliography of the selected articles. Results: We included three randomized clinical trials involving 134 patients. Despite significant heterogeneity, as compared with placebo, Paullinia cupana produced statistically significant improvements in fatigue measured by the Chalder (p <0.00001), Facit F (p = 0.0004) and BFI (p = 0.004) questionnaires. There was no important toxicity related to the Guarana use. Conclusion: We conclude that Paullinia cupana is active for fatigue induced by chemotherapy in patients with solid tumors.


Paullinia cupana; guarana; fatigue; chemotherapy


Objetivo: Revisar a literatura sistematicamente para resumir todos os dados existentes recuperáveis sobre os efeitos anti-fadiga de Paullinia cupana em pacientes tratados com quimioterapia. Métodos: Entre setembro de 2017 e dezembro de 2017, procuramos, nas bases de dados PUBMED, MEDLINE e Cochrane Library. por publicações em inglês de adultos humanos (19 anos ou mais) de pacientes com tumores sólidos submetidos a quimioterapia que receberam Paullinia cupana versus placebo para fadiga. Empregamos os seguintes descritores MeSH (Medical Subject Headings): fadiga, guaraná (Paullinia) e quimioterapia. Também pesquisamos a bibliografia dos artigos selecionados. Resultados: Foram incluídos três ensaios clínicos randomizados envolvendo 134 pacientes. Apesar da heterogeneidade significativa, em comparação com o placebo, Paullinia cupana produziu melhorias estatisticamente significativas na fadiga medida pelos questionários Chalder (p <0,00001), Facit F (p = 0,0004) e BFI (p = 0,004). Não houve toxicidade importante relacionada ao uso de guaraná. Conclusão: Concluímos que a Paullinia cupana é ativa para a fadiga induzida pela quimioterapia em pacientes com tumores sólidos.


Paullinia cupana; guaraná; fadiga; quimioterapia


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